Low resolution typing of loci HLA-A, HLA-B (and HLA-C as an option), HLA-DRB1(optional: HLA-DRB3, HLA-DRB4, HLA-DRB5,HLA-DQA1, HLA-DQB1)
High resolution typing of loci HLA-A, HLA-B (and HLA-C as an option), HLA-DRB1(optional: HLA-DRB3, HLA-DRB4, HLA-DRB5,HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DPB1).
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High resolution typing is defined as the identification of HLA alleles that encode the same protein sequence within the antigen binding site |
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D1.4.1 |
HLA alleles must be identified at the level of resolution which defines the first and second fields according to WHO nomenclature by at least resolving all ambiguities: |
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D1.4.1.1 |
Resulting from polymorphisms located within exons 2 and 3 for HLA class I loci, and exon 2 for HLA class II loci |
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D1.4.1.2 |
That encompass a null allele, wherever the polymorphism is located, unless it can be demonstrated that an expressed antigen is present on the cells |